A peptide hormone that mimics luteinizing hormone (LH) and stimulates testosterone production in the testes. Commonly used during and after anabolic steroid cycles to maintain testicular function and fertility.
Notes
HCG is not a substitute for post-cycle therapy (PCT) but a supportive agent during cycles. Misuse (very high doses, prolonged use post-cycle) can paradoxically suppress the HPG axis. It is banned in most sports and is prescription-only in most countries.
HCG binds to LH receptors on Leydig cells in the testes, triggering the synthesis and release of endogenous testosterone. This helps preserve testicular size, sperm production, and natural hormone levels during periods when exogenous androgens are suppressing the hypothalamic-pituitary-gonadal (HPG) axis.
HCG is a glycoprotein peptide administered by intramuscular or subcutaneous injection. It has a half-life of 24–36 hours and peaks within 6–12 hours post-injection. Clearance is renal; accumulation can occur with frequent dosing.
Typical Dose
250–1000 IU administered 2–3 times per week, depending on cycle context and testicular preservation goals. Some protocols use 500 IU twice weekly during a cycle, or higher doses (1500–2000 IU/week) post-cycle.
Frequency
Two to three times per week
Administration
Intramuscular or subcutaneous injection
Half-Life
~24–36 hours